Singer takes home British Female Solo Artist gong
The Welsh singer won best British Breakthrough Act, British Female Solo Artist and British Album for Rockferry.
But Duffy, 24, lost out to Girls Aloud and their No 1 track The Promise in the Best Single category.
Other winners included Paul Weller (British Male Solo Artist), Elbow (British Group) and Kings Of Leon (International Group).
Kanye West, 31, was named International Male Solo Artist and Katy Perry, 24, took the female equivalent; while the Pet Shop Boys received the Outstanding Contribution To Music Award.
But it was a bad night for Coldplay – despite being nominated for 4 gongs, they went home empty-handed.
Guests at the Earls Court bash included Cheryl Cole, 25, Sir Tom Jones, 68, and David Hasselhoff, 56.
James Corden, Mathew Horne and Kylie Minogue – who changed her outfit 6 times – were the presenters on the night.
Full list of Brit Award winners
Mastercard British Album: Duffy for Rockferry
British Group: Elbow
British Single: Girls Aloud for The Promise
British Male Solo Artist: Paul Weller
British Female Artist: Duffy
British Breakthrough Act: Duffy
British Live Act: Iron Maiden
International Album: Kings of Leon for Only By The Night
International Group: Kings Of Leon
International Male Solo Artist: Kanye West
International Female Solo Artist: Katy Perry
Critic’s Choice Award: Florence & The Machine
British Producer of the Year: Bernard Butler
Outstanding Contribution to Music: Pet Shop Boys