Jeff Bridges also honoured at ceremony
The 45-year-old won the trophy for her role in The Blind Side.
‘I would be a hostess or a waitress or a house restorer before I ever considered myself an actor, because I never thought I was good enough,’ said Sandra.
Jeff Bridges, 60, took home Best Actor for Crazy Heart.
Mo’Nique got Best Supporting Actress for Precious, while Inglourious Basterds‘ Christoph Waltz was Best Supporting Actor.
Golden Girls star Betty White accepted the Lifetime Achievement Award.
Guests at the LA ceremony included George Clooney, Alec Baldwin, Justin Timberlake, Kate Hudson, Mariah Carey and Drew Barrymore.